Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease

Introduction: Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life affected individuals. Methods: In this study, patients underwent clinical follow-ups, biopsies, and pre-biopsy 24 months post-biopsy serum dosage cytokines. Results: All participants were female had pain in 12 joints on average, with 41.17% exhibiting moderate activity. Histopathological analysis revealed collagen deposition. Indirect immunofluorescence detected CHIKV glycoprotein E1 antigen, an increase Conclusions: Persistent inflammation ineffective antiviral immune responses leading to antigen persistence may contribute arthritis.